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I've not experienced any problems mixing charcoals before, including cocochar with regular lump. I've never cooked that many butts at once before, so I do not have a lot of advice. If you keep them on the same level, just don't crowd them too much to block airflow between them. If you put them on the main and upper grates they will cook at different rates, so just be careful to monitor at least one on each level. Otherwise, you sound good to go! Butts are seriously hard to mess up, so you're going to be fine!

I always use the coco extruded and lump together for low-slow cooks, no issues at all. I have done 4 butts at once on my 23" several times, no problems, two on main grate, two on upper grate; the upper grate one touched a bit, but that did not present any issues. I ran them for about 14-16 hours but used internal temp of 190f to determine finish time. I only monitored one on the main grate. once internal is hit, wrap in foil, stick in cooler, shred when needed.