It's been a few years, but I've made many batches of fermented Tabasco-style hot sauce over the years.
Like many of us, I have a chamber vacuum machine. The signature uses of sous vide and freezer preservation easily justify a machine. Nevertheless, we should all take inspiration from those "what goes in a blender?" YouTube videos.
What goes in a chamber vacuum machine?
A couple of sixty second sessions will hydrate any dough better than a long rest. This has an extraordinary effect on pasta dough.
A quick refrigerator pickle such as a Mexican Cauliflower and Jalapeño Escabeche (Asada: The Art of Mexican-Style Grilling by Bricia Lopez and Javier Cabral has the best recipe I've seen) benefits from vacuum packing and a rest.
Some people ferment chiles for hot sauce by vacuum packing the peppers with a starter, in a large pouch with room for the gases.
The challenge in fermenting chiles is getting white cloudy Kahm Yeast. While it isn't harmful, it's gross, and in my opinion it affects the flavor. The fermenting world is full of people who've never figured out how to avoid Kahm yeast, who consider worrying about it a silly concern. I usually don't get Kahm yeast, but I consider myself an abject failure of a human being when I do.
The hope is that removing oxygen by chamber vacuum sealing the chiles will prevent Kahm Yeast.
I also have an argon tank, for saving part bottles of wine, and I intend to experiment with displacing the air in a carboy, as an alternate approach.
I adjust pH to below the botulism threshold whatever I do, measuring with a professional pH meter. You can get banned from a fermentation forum by suggesting such a thing, but it brings me peace of mind.
Many botulism deaths are the result of ill-advised experiments that break with long understood tradition, such as Alaskan natives fermenting meats in a plastic pail rather than in the traditional sealskin. One should recognize that any novel approach to fermenting hot sauce poses similar questions.